Preparing for Our Future

Because we had a successful site review in May of 2015, funding looks good to finish out the five year grant, ending in Summer 2017.  At the same time trends indicate that this type of collaborative funding is changing – so we also talked about our strengths as a scientific community to prepare ourselves for long term sustainability in that future funding environment, and brainstorm ways to be responsive to feedback – for different funding arrangements and possibilities, as things move forward.

In that vein, on September 4th, 2015 – our larger membership and advisory teams came together to hear the very latest science in our labs and in our larger community, as well as to talk about our fourth and fifth NIGMS P50 grant years, and farther out.  Nearly fifty members attended including a shooting star list of speakers and poster presenters:

Marina Volegova – Cate Lab, Functional characterization of eIF3a in relation to non-canonical translation initiation

Kevin Doxzen – Doudna Lab, Structural insights into a novel prokaryotic argonaute 

Meghan Zubradt – Weissman Lab, DMSseq 2.0: Steps toward single-molecule mRNA structure determination

Harold Pimentel – Pachter Lab, Quantification and analysis of RNA transcripts

David Weinberg – UCSF Faculty Fellow, Guest Presenter, New lessons from an old RNA:Revisiting the post-transcriptional silencing of unspliced HAC1 mRNA

Poster Presenters:

Amy R. Eisenberg Brar Lab, Translation elongation regulation in budding yeast meiosis

Stephen Floor Doudna Lab, Tunable protein synthesis by transcript isoforms in human cells

Tania L. Gonzalez Hammond Lab, Tight, inducible regulation of plant immune responses by combining promoter and suicide exon elements

Shintaro Iwasaki Ingolia Lab, Rocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor

Yeon Lee Hammond & Rio Labs, Systems Level Analysis of Alternative Pre-mRNA Splicing: The roles of RNA structure and RNA Chaperone Proteins

James Peter Brook Lloyd Brenner Lab, Characterizing the regulation of splicing factors by alternative splicing and nonsense-mediated mRNA decay

Ryan Muller Rio & Hammond Labs, Cas9-Mediated Manipulation of Alternative Splicing

Mia Pulos & Luisa Tacca Cate & Ingolia Labs, Pathways under eIF3-directed translational regulation

Dan Santos Weissman Lab, Investigating protein multi-functionality and translational regulation using ribosome profiling

Duane Smith Cate Lab, Modulation of calcineurin signaling by dysregulation of non-essential eIF3 subunits

2015 Undergrad CRSB-Amgen Fellows

Paige Diamond, Mentor – Faculty – Dr. Gloria Brar Brar Lab, Systematic identification of alternative ORF translation in meiotic yeast cells

Lauren A. Thurlow; Mentor – Dr. Audrone Lapinaite Cate & Doudna Labs, A Fluorescently Labelled dCas9 for Imaging Endogenous RNAs In Vivo