CRSB Discovers RNA Targets for Anticancer Drugs


CRSB discovers RNA targets for anticancer drugsJamie Cate, UC Berkeley professor of molecular and cell biology, CRSB Director, and postdoctoral fellows Amy Lee and Philip Kranzusch have found that a small subset of mRNAs coding for proteins are linked in some way to cancer.

“We’ve discovered a new way that human cells control cancer gene expression, at the step where the genes are translated into proteins. This research puts on the radar that you could potentially target mRNA where these tags bind with eIF3,” Cate said. “These are brand new targets for trying to come up with small molecules that might disrupt or stabilize these interactions in such a way that we could control how cells grow.”

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