************************************
Computational Biology Seminar
************************************

Tuesday, April 7, 2015
4:00–5:00pm
125 Li Ka Shing Center

Title:  Combining Genetics and Genomics to Gain Biological Insights

Please join us for the Computational Biology Seminar next Tuesday, April 7th at 4pm featuring Dr. Chris Cotsapas from the Department of Neurology, Yale School of Medicine.

Abstract:

As genetic and genomic studies become routine, new approaches are required to wrest biological insights from these data. These approaches must address the multifactorial nature of complex traits, the gene regulatory effects likely driving much of that architecture, and recognize that mechanisms can be used in multiple cell types across many contexts. We have begun to combine genetic and genomic data to gain insight into mechanisms underlying autoimmune and inflammatory diseases, to identify suites of genes whose regulation is altered to induce risk; the specific cells and stimuli in which these alterations are risk-relevant; and develop assays to test these responses in a therapeutic development setting. I will discuss our recent findings of NFkB-mediated regulatory alterations driving MS risk, selective constraint in early fetal brain development, and testing how rare coding variants alter cell-cell interactions.

Bio:

Dr. Chris Cotsapas is a computational geneticist whose primary interest is in understanding the biological processes underlying diseases of the immune system. He has published several highly cited papers on genome-wide association studies of disease, gene expression genetics and evolutionary biology. Chris obtained his BSc in Biochemistry from Imperial College London in 2000 and his PhD in Biochemistry and Molecular Genetics from the University of New South Wales, Sydney in 2007.