File Name: basic principles of biopharmaceutics and pharmacokinetics .zip
If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Please consult the latest official manual style if you have any questions regarding the format accuracy. Drugs are substances intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease.
Handbook of Space Pharmaceuticals pp Cite as. Later version available View entry history. Despite more than 50 years of manned spaceflight, we still barely know if the medications that astronauts receive in space are as effective and safe as they are on Earth. The unique spaceflight environment may disrupt the physiological balance in astronauts, leading to alterations of pharmacokinetics and pharmacodynamics of therapeutic agents. To ensure that crewmembers receive efficacious and safe medications in space, it is critical to understand the unusual pharmacological responses of medications during missions. However, the field of space pharmacology has not been systematically evaluated yet. This chapter offers a review of basic principles of biopharmaceutics with special focus on pharmacokinetics and discusses how the potential physiological changes in space can influence the absorption, distribution, metabolism, and excretion of pharmacologic agents.
Pharmacokinetics from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics , sometimes abbreviated as PK , is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs , pesticides , food additives , cosmetics , etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics PD is the study of how the drug affects the organism. These may affect the absorption rate. Models have been developed to simplify conceptualization of the many processes that take place in the interaction between an organism and a chemical substance.
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